Shakiryanova's vesicle mobility paper (2007)

It has been postulated that vesicle mobility is increased to enhance release of transmitters, its mechanism was unknown.

Ryanodine receptor mediated Ca2+-induced Ca2+ release from ER is necessary for the sustained DCV mobilization.
This RyR-receptor mediated release is short-lived, and triggers activation of CaMKII as a downstream activator.

ryanodine (high purity) and other chemicals were purchased from Calbiochem.

4-bromo-clacimycin is a Ca2+ ionophore.

cytosolic calcium sensor, Cameleon 2.1.

CaMKII activity can be blocked by a membrane-permiable version of AIP-II (Antennapedia peptide fused).

veratridine, a sodium channel opener (that results in an increase of intracellular Ca2+).