Neurotrophins mediates a rapid switch in transmitter release

Bo Yang, John D. Slonimsky and Susan J. Birren

Brain-derived neurotrophic factor (BDNF) altered the neurotrasmitter release properties of sympathetic neuron-myocyte connections in rodent cell culture, leading to a rapid shift from excitatory norepinephrinic transmission to inhibitory cholinergic trasmission.

p75 neurotophin receptor mediates modulation of release of distinct neurotransmitter pools, resulting functinoal switch between excitatory and inhibitory neurotoransmission in individual neurons.

Nature Neuroscience 5(6) 539-545 (2002).