Grae Davis gave a Brains and Behavior talk entitled, "Homeostatic Control of Neural Function: From Phenomenology to Molecular Design".
He talked about homeostasis of the transmitter release that compensates reduced sensitivity or motoneuronal innervation of the postsynaptic muscle. If postsynaptic GluR was blocked by a toxin, the frequency of mEPSC increases and the size of EPSP recovers in 10 min. This was shown also by some mutants.
This recovery of EPSP amplitude is activity-independent. It seems like that the muscle is sensing the tonic release of transmitter from the presynaptic terminals, and release some retrograde messenger that regulates the transmitter release.
One candidate was called ephrins and Eph receptor.
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