Sunday, May 17, 2009

Voltage-dependent switching of sensorymotor integration by a lobster central pattern generator

By Romuald Nargeot

- Repeated sensory nerve stimulation gradually and long-lastingly strengthened the bursting of the LP neuron to the detriment of sensory-elicited inactivation.

- This strengthening of pyloric-timed rhytmic activity as enhanced by experimental depolarization of the neuron.

- When the LP neuron was hyperpolarized, the same sensory stimulation paradigm now gradually increased the susceptibility of the pyloric-timed bursting of the network neuron to sensory-elicited inactivation.

- Modulation of depolarization-activated and hyperpolarization-activated ionic conductances that underlie the intrinsic bursting properties of the LP neuron may contribute via differential voltage-dependent recruitment and effects to the respective adaptive processes.

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